In other words, I can't tell yet whether mek even knows what we mean by "profile" (we specifically mean: as chosen in drop-down list in camera calibration section of develop module).
For the mentioned camera (D300), the Adobe supplied camera matching profiles are virtually identical to the in-camera rendering using the same picture style. I have used this camera for a long time with Lightroom and you would be very hard pressed to see the difference. The Adobe folks have worked hard on this camera as I send them lots of raw files to test. Of course if you enable crappy HDR modes in camera (Nikon calls these modes things like active D-lighting), you'll end up with underexposed images in Lightroom, because that is exactly what the camera does, underexpose and correct in post. If you are a raw shooter, ignore all the in-camera settings and as Rob mentions earlier, shoot in a mode that is very neutral and allows you to see the full breadth of what is captured and do your post ..... in post. You'll get FAR better quality images than optimizing in camera raw rendering settings. Lightroom is lightyears ahead of Nikon's software in almost every aspect, especially including rendering of raw files, let alone user interface.